Comprehensive Research Report: June–November 2025
First-in-class neuroimmune modulation device for rheumatoid arthritis. 75% of patients free of biologics at 12 months. Once-daily vagus nerve stimulation activates anti-inflammatory pathways.
First targeted therapy for Sjögren's disease showing sustained efficacy through 52 weeks. Dual-mechanism antibody targeting B-cell depletion and BAFF receptor blockade.
University of Chicago launched Phase 2 trials for lupus, myositis, and systemic sclerosis. Cabaletta Bio demonstrated drug-free clinical responses without preconditioning chemotherapy.
83% of patients (10/12) remained insulin-independent one year after stem cell-derived therapy. HbA1c <7% and >70% time-in-range achieved, demonstrating physiological islet function restoration.
| Cost Category | Amount | Impact |
|---|---|---|
| Annual National Healthcare Costs | $100+ Billion | NIH estimate |
| Excess Costs Per Employee | $2,200-$33,500 | Annually |
| Employer Costs (per 1,000 employees) | $580,000 | 5 major conditions |
| Medical Costs Increase | Up to 6x | vs general population |
| Prescription Costs Increase | Up to 16x | vs general population |
| Average Lost Work Days (STD) | 73 days/year | $27,000 economic value |
| Medicare Part D Out-of-Pocket Cap | $2,000 | Effective Jan 2025 |
| Finding | Evidence Level | Details |
|---|---|---|
| Serious Adverse Events | Low certainty | Little or no serious adverse events reported |
| Thrombotic Events | Moderate certainty | Less frequent in vaccinated populations |
| Myocarditis | Low certainty | Lower risk in vaccinated vs unvaccinated |
| Disease Exacerbations | Moderate certainty | Do not increase due to vaccination |
| MS Lesions on Imaging | Low certainty | Reported in one study, clinical implications uncertain |
Toni Bailey is a leading patient advocate and research specialist in autoimmune and rare diseases.As co-founder of Oregon Coast AI, Toni has the capabilities to research emerging trends in diagnostics, treatment, and patient-reported outcomes, helping to close the gap between clinical research and real-world patient needs. With a background that bridges personal patient experience with deep expertise in medical data analysis, Toni is dedicated to translating complex scientific breakthroughs into accessible, empowering insights for patients and caregivers.